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Träfflista för sökning "WFRF:(Chaim K. T.) srt2:(2015-2019);pers:(Criswell Lindsey A.);pers:(Guthridge Joel M.)"

Search: WFRF:(Chaim K. T.) > (2015-2019) > Criswell Lindsey A. > Guthridge Joel M.

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1.
  • Langefeld, Carl D., et al. (author)
  • Transancestral mapping and genetic load in systemic lupus erythematosus
  • 2017
  • In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 8
  • Journal article (peer-reviewed)abstract
    • Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (similar to 50% of these regions have multiple independent associations); these include 24 novel SLE regions (P < 5 x 10(-8)), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE.
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2.
  • Kottyan, Leah C., et al. (author)
  • The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.
  • 2015
  • In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 24:2, s. 582-596
  • Journal article (peer-reviewed)abstract
    • Exploiting genotyping, DNA sequencing, imputation and trans-ancestral mapping, we used Bayesian and frequentist approaches to model the IRF5-TNPO3 locus association, now implicated in two immunotherapies and seven autoimmune diseases. Specifically, in systemic lupus erythematosus (SLE), we resolved separate associations in the IRF5 promoter (all ancestries) and with an extended European haplotype. We captured 3230 IRF5-TNPO3 high-quality, common variants across 5 ethnicities in 8395 SLE cases and 7367 controls. The genetic effect from the IRF5 promoter can be explained by any one of four variants in 5.7 kb (P-valuemeta = 6 × 10(-49); OR = 1.38-1.97). The second genetic effect spanned an 85.5-kb, 24-variant haplotype that included the genes IRF5 and TNPO3 (P-valuesEU = 10(-27)-10(-32), OR = 1.7-1.81). Many variants at the IRF5 locus with previously assigned biological function are not members of either final credible set of potential causal variants identified herein. In addition to the known biologically functional variants, we demonstrated that the risk allele of rs4728142, a variant in the promoter among the lowest frequentist probability and highest Bayesian posterior probability, was correlated with IRF5 expression and differentially binds the transcription factor ZBTB3. Our analytical strategy provides a novel framework for future studies aimed at dissecting etiological genetic effects. Finally, both SLE elements of the statistical model appear to operate in Sjögrens syndrome and systemic sclerosis whereas only the IRF5-TNPO3 gene-spanning haplotype is associated with primary biliary cirrhosis, demonstrating the nuance of similarity and difference in autoimmune disease risk mechanisms at IRF5-TNPO3.
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Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Martin, Javier (2)
Kelly, Jennifer A. (2)
Kaufman, Kenneth M. (2)
Guthridge, Joel ... (2)Undo refine
Ramsey-Goldman, Rosa ... (2)
Reveille, John D. (2)
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Vila, Luis M. (2)
Freedman, Barry I. (2)
Jacob, Chaim O. (2)
James, Judith A. (2)
Kamen, Diane L. (2)
Merrill, Joan T. (2)
Tsao, Betty P. (2)
Langefeld, Carl D. (2)
Harley, John B. (2)
Gaffney, Patrick M. (2)
Gunnarsson, Iva (1)
Svenungsson, Elisabe ... (1)
Scherbarth, Hugo R (1)
Berbotto, Guillermo ... (1)
García, Mercedes A (1)
Truedsson, Lennart (1)
Alarcón-Riquelme, Ma ... (1)
D'Alfonso, Sandra (1)
Baca, Vicente (1)
Orozco, Lorena (1)
Witte, Torsten (1)
Ortego-Centeno, Norb ... (1)
Pons-Estel, Bernardo ... (1)
Alarcón-Riquelme, Ma ... (1)
Nordmark, Gunnel (1)
Wahren-Herlenius, Ma ... (1)
Carlsson Almlöf, Jon ... (1)
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Lessard, Christopher ... (1)
Anaya, Juan-Manuel (1)
Bae, Sang-Cheol (1)
Boackle, Susan A. (1)
Brown, Elizabeth E. (1)
Edberg, Jeffrey C. (1)
Gregersen, Peter K. (1)
Gilkeson, Gary S. (1)
Kimberly, Robert P. (1)
Niewold, Timothy B. (1)
Stevens, Anne M. (1)
Vyse, Timothy J. (1)
Frostegard, Johan (1)
Cervera, Ricard (1)
Sjöwall, Christopher (1)
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University
Uppsala University (2)
Linköping University (2)
Karolinska Institutet (2)
Umeå University (1)
Lund University (1)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)

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